Figure 2.

Airway hyperresponsiveness in mice treated with different concentrations of As₂O₃. The mice treated with 2.5 mg/kg of As₂O₃ had a significant decrease in airway hyperresponsiveness. Animals administered 5 mg/kg of As₂O₃ had a lower Penh value than the control group. Each group included four to five mice. Values are expressed as mean±SEM. The difference is statistically significant compared with the control group (*P<0.05). As₂O₃, arsenic trioxide; ATO, arsenic trioxide; PBS, phosphate-buffered saline; Penh, enhanced pause; OVA, ovalbumin.