Figure 6.

Twenty-four hours of treatment with As₂O₃ induces apoptosis in primary pulmonary cells in a dose-dependent manner (a). As₂O₃ of 0.05 µΜ inhibits the secretion of eotaxin by pulmonary cells stimulated with IL-4 (3000 U/ml) (b) and the secretion of RANTES by pulmonary cells stimulated with TNF-α (20 ng/ml) (c). Values are expressed as mean±SEM. The difference is statistically significant compared with the control group (*P<0.05). As₂O₃, arsenic trioxide; RANTES, regulated upon activation, normal T cell expressed and secreted; TNF, tumor necrosis factor.