Table 1. Effects of ZK14 on serum ALT, AST, HA, PCIII, and NO level in hepatic fibrosis rats induced by CCl4. Mean±SD. bP<0.05, cP<0.01 vs normal. eP<0.05, fP<0.01 vs model.
Groups | Dose (mg/kg) | n | ALT (U/L) | AST (U/L) | HA (ng/mL) | PCIII (ng/mL) | NO (μg/L) |
---|---|---|---|---|---|---|---|
Normal | / | 6 | 22.73±3.5 | 113.35±11.35 | 248.19±37.53 | 7.85±2.15 | 50.69±15.37 |
Model | / | 8 | 50.12±12.56b | 222.83±25.36b | 1017.45±52.84c | 35.36±9.70c | 42.34±14.21 |
ZK14 | 20 | 10 | 35.74±7.05e | 145.19±34.77e | 422.27±56.23f | 20.93±6.73f | 154.84±29.49c |
ZK14 | 10 | 10 | 47.16±25.72 | 208.41±32.45 | 957.62±52.01 | 39.88±8.45 | 96.67±20.45b |
DDB | 5 | 10 | 27.47±30.37e | 136.79±30.43e | 967.46±66.32 | 32.72±8.78 | 46.88±12.20 |