Table 2. Response values of different variables for the optimization of BPC preparation using the spherical symmetric design-response surface methodology.

Formulation	Factors			Responses
	X1	X2	X3	Y1	Y2
1	−1	−1	−1	100.00	34.70
2	−1	−1	1	98.82	47.02
3	−1	1	−1	67.19	26.76
4	−1	1	1	76.19	43.06
5	1	−1	−1	97.82	37.22
6	1	−1	1	90.25	46.13
7	1	1	−1	98.44	35.91
8	1	1	1	96.85	47.07
9	−1.732	0	0	65.27	32.97
10	1.732	0	0	99.12	43.50
11	0	−1.732	0	100.00	45.78
12	0	1.732	0	90.11	45.36
13	0	0	−1.732	100.00	26.94
14	0	0	1.732	90.74	49.85
15	0	0	0	100.00	41.41