. 2010 Jan 5;31(1):51–65. doi: 10.1038/aps.2009.187

Table 1. Summary of the impact of prototypical inducers (Chenodeoxycholiic acid; CDCA, Pregnane 16α-carbonitrile; PCN, Phenobarbital; PB and Rifampicin; RIF), on gene expression in H411e, Iec-6, and rat primary hepatocytes. For clarity, statistical analyses for cell lines H411e and Iec-6 are given only for the lowest concentration at which a significant difference was observed. For primary hepatocytes, the incubation time (in hours) when significant induction was detected: ^bP<0.05, ^cP<0.01.

	H411e Test compound (μmol/L)				Iec-6 Test compound (μmol/L)				Primary hepatocytes Test compound at 1 μmol/L (Incubation time in hours)
Gene	CDCA	PCN	PB	RIF	CDCA	PCN	PB	RIF	CDCA	PCN	PB	RIF
CYP2B2	0.1^c	0.1^c	10^b	NS	1^c	0.1^c	NS	NS	2^c	2^c	2^b	NS
CYP3A1	10^b	0.1^c	10^b	1^c	0.1^c	0.01^c	1^c	0.1^b	2^c	2^b	2^c	2^c
CYP3A2	NS	0.1^c	10^b	1^c	NS	10^c	1^b	1^c	2^c	2^c	2^c	2^c
CYP3A9	0.1^c	0.1^c	10^c	0.01^b	NS	0.01^c	0.01^c	0.1^c	2^c	2^c	2^c	2^c
ABCC1	1^c	1^c	NS	1^c	1^c	1^c	NS	1^b	4^b	2^c	2^b	4^b
ABCC2	1^b	1^c	10^c	1^c	NS	NS	1^b	1^c	2^c	2^b	2^b	2^b
ABCB1a	0.01^c	0.01^c	0.01^c	0.01^c	0.01^c	0.01^c	0.01^c	0.01^c	2^b	2^c	2^c	4^c
ABCB1b	0.1^c	0.01^c	0.01^c	0.1^c	1^c	0.01^c	0.01^c	0.1^c	2^c	2^b	2^c	2^c
FXR	1^c	0.1^c	NS	1^c	0.1^b	NS	NS	NS	2^c	NS	NS	NS
PXR	10^b	NS	0.1^c	1^c	1^b	0.1^b	0.1^b	0.1^c	NS	2^b	2^c	2^c
CAR	1^c	1^c	10^c	1^c	1^c	0.1^b	0.1^c	0.1^c	2^b	4^b	2^c	2^c