Figure 5.

Combined inhibition of tumor angiogenesis in vivo. (A) Immunohistochemical detection for CD34 expression in 4T1 breast carcinoma sc xenografted tumors. Representative pictures for different treatment groups are shown. The positive expression of CD34 was mainly represented as brownish yellow or brownish granules in tumor vascular endothelial cells. (B) The tumor MVD in different treatment groups. PDT plus ADM combination treatment synergistically inhibited in vivo angiogenesis of 4T1 breast carcinoma sc xenografted tumors (^cP<0.01 vs control group, one-way repeated measures ANOVA and multiple comparisons, n=6 mice per condition, n=5 observations per representative section). ^fP<0.01 vs PDT or ADM single treatment group.