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. 2011 Sep 19;32(11):1387–1396. doi: 10.1038/aps.2011.107

Figure 7.

Figure 7

mRNA expression of the DNA repair enzymes ERCC1, MLH1, PMS2, and MSH2 in the CRC cell lines following 48 h satraplatin treatment. The CRC cells demonstrated unrepaired DNA damage owing to a down-regulation of the expression of DNA damage responsive genes in all cell lines tested. Only the expression of MSH1 and ERCC1 was up-regulated in the HCT116 wild-type cells. The fold change is based on the normalization of ACTB and B2M proteins in the treated vs the untreated control cells. The results shown are representative of at least two independent experiments.