MMC treatment at 1, 1.5 or 2 mg/kg in combination with curcumin at 100 mg/kg produced effects on reducing tumor quality and body weight compared with either treatment alone. (A) The growth-inhibitory effect of MMC at 1 mg/kg (M1), 1.5 mg/kg (M1.5), and 2 mg/kg (M2), curcumin 100 mg/kg (Cur) and their combination on MCF-7 xenografts is shown. bP<0.05 vs 1.5 mg/kg MMC in combination 100 mg/kg curcumin-treated group. (B) Body weights of MCF-7 xenografts were measured after animals were treated with or without MMC, curcumin or a combination for 4 weeks. aP>0.05 vs normal group. Experiments were repeated with similar results.