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. 2011 Oct 10;32(11):1402–1410. doi: 10.1038/aps.2011.97

Figure 6.

Figure 6

MMC treatment at 1, 1.5, or 2 mg/kg in combination with curcumin at 100 mg/kg downregulated the levels of cyclin D, cyclin E, cyclin A, CDK2, and CDK4 and upregulated p21 and p27 levels. The MCF-7 xenografts were treated with either curcumin at 100 mg/kg or MMC at 1, 1.5, and 2 mg/kg alone or in combination, and Western blot analysis was performed with antibodies specific to cyclin D1, cyclin E, cyclin A, CDK2, CDK4, p21, p27, and p-p38. The density ratio of proteins to GAPDH was shown as a relative expression. bP<0.05 vs 1.5 mg/kg MMC in combination with 100 mg/kg curcumin-treated group. eP<0.05 vs 2 mg/kg MMC in combination with 100 mg/kg curcumin-treated group. Values are mean±SD from 3 independent experiments.