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Effects of repeated ip injections of dexmedetomidine (DEX) on increase in GFAP (a astrocytic marker) expression in the spinal dorsal horn induced by monoarthritis (MA). (A) Immunohistochemistry for GFAP in the ipsilateral spinal transverse sections on day 5 after sham MA, MA, and MA with multiple DEX-treatment. (B) Quantification of GFAP expression on both sides of the spinal dorsal horn. cP<0.01 (n=4).
