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. 2011 Jan 31;32(3):375–384. doi: 10.1038/aps.2010.206

Figure 3.

Figure 3

Inverse correlation between miR-221 and CDKN1C/p57 in CRC samples. (A) CDKN1C/p57 protein levels in CRC and matched non-tumorous tissues. A reduction of CDKN1C/p57 protein levels can be observed in several CRCs (total proteins, from the same samples utilized for RT-PCR in Figure 1B, were analyzed by Western-blot with anti-p57 antibodies. β-actin was used as house-keeping gene to normalize CDKN1C/p57 protein expression). Note: N, T represented the patients' non-tumorous tissues (N) and CRCs (T), respectively. (B) Inverse correlation between miR-221 and CDKN1C/p57 in CRC tissues. MiR-221 quantitation was obtained by real-time RT-PCR, whereas CDKN1C/p57 protein expression was evaluated by Western-blot analysis. A statistically significant inverse correlation between miR-221 and CDKN1C/p57 protein levels was observed (P<0.01).