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. 2011 Mar 4;32(3):338–344. doi: 10.1038/aps.2010.219

Figure 4.

Figure 4

Effects of ST1 and ST2 on the AR transcriptional activity in LNCaP cells (A) Luciferase activity in LNCaP cells transfected with the pGL3-PSA 6 kb promoter luciferase reporter following treatment with STs for 24 h. (B) Luciferase activity in PC3 cells co-transfected with the pGL3-PSA 6 kb promoter reporter and a human AR expression construct following exposure to STs as indicated for 24 h. (C) Luciferase activity in LNCaP cells transfected with the pGL3-SV40-hk2-3ARE reporter following treatment with STs for 24 h. (D) Luciferase activity in PC3 cells co-transfected with the pGL3-SV40-hk2-3ARE reporter and a human AR expression construct following treatment with STs as indicated for 24 h. bP<0.05, cP<0.01 vs Mib treatment. The parental vectors pGL3 basic vector and pGL3-SV40 were included as controls. The phRL-TK, co-transfected in each transfection, was the internal control for normalization. The normalized relative luciferase activity (mean±SD) of at least three independent experiments is shown.