Table 1. Microarray analysis of miRNA expression in human gliomas U251 cells treated with ginsenoside Rh2.

miRNA	Fold (Mean±SEM)	P value	Localization	Up-down regulation
miR-15b	3.15±0.18	0.015	17q23.1	up
let-7c	2.03±0.15	0.010	21q11.2	up
let-7d	2.97±0.25	0.024	7q22.1	up
miR-29b	2.32±0.21	0.017	6q23.31	up
miR-106b	2.26±0.17	0.005	7q22.1	up
miR-125b	2.88±0.30	0.020	11q24.1	up
miR-128	3.04±0.19	0.013	2q21.3	up
miR-129	2.54±0.24	0.014	7q32.1	up
miR-137	2.13±0.14	0.008	1q21.3	up
miR-138	2.29±0.11	0.009	3q21.33	up
miR-181a	2.41±0.22	0.011	1q32.1	up
miR-181b	2.62±0.26	0.021	1q32.1	up
miR-181c	2.35±0.23	0.017	19p13.3	up
miR-323	2.57±0.18	0.013	14q32.31	up
miR-16	0.41±0.07	0.001	21q11.2	down
miR-18	0.37±0.10	0.007	9q22.2	down
miR-21	0.17±0.04	0.000	17q23.1	down
miR-25	0.23±0.09	0.003	7q22.1	down
miR-32	0.43±0.18	0.009	11q24.1	down
miR-92	0.39±0.11	0.005	21q11.2	down
miR-107	0.37±0.13	0.006	7q32.1	down
miR-155	0.28±0.09	0.002	3p21.33	down
miR-210	0.45±0.11	0.005	11p15.5	down
miR-218	0.37±0.21	0.012	4p15.31	down
miR-328	0.42±0.12	0.007	16q22.1	down
miR-370	0.38±0.07	0.003	14q32.2	down

1. The results presented fold change of signal ratio of 12 μg/mL Rh2-treated cells to untreated control cells.

2. The raw data were normalized and analyzed with software of MatLab version7.4, which produced an average value of the four spot replications of each miRNAs.

3. Chromosome localization of microRNAs as refered in miRBase sequences (http://microrna.sanger.ac.uk).