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Concentrations of phenytoin and carbamazepine in the cortical extracellular fluid. The concentrations of AEDs were measured by HPLC. The concentrations of PHT (A) and CBZ (B) in the cortical extracellular fluid after intraperitoneal injection are shown (n=8). Control, electrode-implanted control rat; Epilepsy, epileptic rat; Probenecid, epileptic rat with probenecid pre-treatment.
