Figure 3.

Induction of therapeutic antitumor immunity. Mice (8 per group) were immunized once weekly for 4 weeks with T4-mFlt4 (1×10¹⁰–1×10¹³ pfu/mL; 100 μL per mouse) (groups are presented as ×, ▪, and □, respectively), the blank T4 phage in SM (blank T4 phage group) (○), or SM alone (○), starting at day 7 after 1×10⁶ Lewis lung carcinoma cells (LLC) were introduced subcutaneously into mice. Results are expressed as means±SEM. No significant differences were found between groups with respect to tumor size (P>0.05) (A). However, the survival length in tumor-bearing mice was extended in the T4-mFlt4 groups compared with the untreated groups (B).