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. 2010 Feb 5;31(2):137–144. doi: 10.1038/aps.2009.196

Figure 1.

Figure 1

Effects of baicalin and zileuton on cell injury induced by OGD/recovery in PC12 cells. Cell viability was reduced after 2-h OGD and 24-h recovery in both GFP- and GFP-5-LOX-transfected cells. (A and B) Viability was significantly lower in GFP-5-LOX-transfected cells than in GFP-transfected cells. Baicalin and zileuton attenuated OGD/recovery-induced injury in both type cells in a concentration-dependent manner. (C) Cell death (necrosis) was evaluated by PI fluorescence staining in GFP-5-LOX-transfected PC12 cells (Scale bar=40 μm). (D and E) Baicalin and zileuton inhibited OGD/recovery-induced cell death in a concentration-dependent manner. Data are reported as mean±SD. n=15−17 (A and B) or 4 (D and E). bP<0.05, cP<0.01 vs corresponding control; eP<0.05, fP<0.01 vs OGD/recovery alone; hP<0.05, iP<0.01 vs GFP-transfected cells.