Figure 4.

Effects of baicalin and zileuton on OGD/recovery-induced ROS production and H₂O₂-reduced viability in PC12 cells. (A and B) ROS production was determined after 2-h OGD and 0.5-h recovery in the absence or presence of baicalin and zileuton in wild-type PC12 cells. Baicalin, but not zileuton, inhibited ROS production. (C and D) Exposure to H₂O₂ (160 mol/L) for 24 h reduced cell viability in GFP-5-LOX-transfected PC12 cells. Over-expression of 5-LOX augmented H₂O₂- induced injury in PC12 cells. Baicalin (C) and zileuton (D) attenuated the reduced viability. Data are reported as mean±SD. n=8. ^bP<0.01, ^cP<0.01 vs control; ^eP<0.05, ^fP<0.01 vs OGD alone; ^hP<0.05, ⁱP<0.01 vs GFP-transfected cells.