Table 2. Biological processes significantly regulated by AA in HK-2 cells.
| Biological processes | Genes | 10 ×mol/L _P | 30 ×mol/L_P | 90 ×mol/L_P |
|---|---|---|---|---|
| DNA repair | 166 | 3.15×10−7 | 7.70×10−5 | 1.75×10−7 |
| Response to DNA damage stimulus | 122 | 5.40×10−7 | 2.00×10−4 | 2.20×10−6 |
| Macromolecule metabolic process | 202 | 4.07×10−6 | 3.00×10−4 | 3.18×10−6 |
| Carbohydrate metabolic process | 205 | 4.90×10−5 | 4.00×10−4 | 6.17×10−5 |
| DNA metabolic process | 236 | 1.00×10−4 | 3.70×10−3 | 7.43×10−7 |
| Apoptosis | 295 | 4.00×10−4 | 1.60×10−3 | 1.19×10−5 |
| Cell cycle | 169 | 2.40×10−3 | 3.04×10−2 | 8.30×10−6 |
| Transcription | 148 | 5.40×10−3 | 3.80×10−3 | 2.20×10−5 |
The biological pathways affected by AA in HK-2 cells were examined by 'GeneSetTest' function in the Limma package. This function computes a P-value to test the hypothesis that the selected genes in a pathway tend to be differentially expressed. “P” indicated P values.