Table 3. Estimates of various pathways regulated by different doses of AA.

Pathway	10 μmol/L_P	30 μmol/L_P	90 μmol/L_P	10 μmol/L_s	30 μmol/L_s	90 μmol/L_s
Cytokine-cytokine receptor interaction	<2.20×10−16	<2.20×10−16	<2.20×10−16	<−15.66	<−15.66	<−15.66
TNF signaling pathway	2.00×10−7	5.70×10−5	<2.20×10−16	−6.40	−3.94	<−15.66
Interleukin signaling pathway	4.05×10−5	1.37×10−4	<2.20×10−16	−4.09	−3.56	<−15.66
Hematopoietic cell lineage	3.45×10−5	3.10×10−6	4.30×10−5	−4.16	−5.21	−4.07
Cell adhesion molecules (CAMs)	3.75×10−4	7.20×10−6	4.40×10−6	−3.13	−4.84	−5.06
Insulin signaling pathway	3.13×10−4	2.00×10−6	6.84×10−5	−3.20	−5.40	−3.86
IFN signaling pathway	5.44×10−5	4.03×10−4	2.80×10−6	−3.96	−3.09	−5.25
Long-term depression	5.73×10−4	3.24×10−5	1.95×10−5	−2.94	−4.19	−4.41
IL-2 signaling pathway	3.04×10−4	3.19×10−5	3.64×10−4	−3.22	−4.20	−3.14

Pathways with P values <0.001 (scores >2.7 or <−2.7) calculated by “GeneSetTest” function in all AA treatments were considered differentially regulated. Pathway analysis revealed that 9 pathways were regulated in all AA treatments. The minus sign of scores in each pathway meant that all AA treatments downregulated every pathway. The results of this study were in triplicate. “P” indicated P values and “s” indicated score.