Table 4. Gene list of NF-κB connected significantly regulated genes in AA- treated HK-2 cells.
| Symbol |
Description |
10 μmol/L AA |
30 μmol/L AA |
90 μmol/L AA |
|||
|---|---|---|---|---|---|---|---|
| FC±SD | P value | FC±SD | P value | FC±SD | P value | ||
| AOC3 | Amine oxidase, copper containing (vascular adhesion protein 1) | 3 3.8±0.53 | 1.54×10−2 | 10.16±1.55 | 5.94×10−3 | 10.25±1.66 | 4.46×10−3 |
| CCL20 | Chemokine (C-C motif) ligand 20 | −11.46±2.20 | 2.15×10−3 | −11.4±1.04 | 4.31×10−4 | −17.4±4.26 | 5.29×10−4 |
| CCND2 | Cyclin D2 | −2.24±0.13 | 8.18×10−3 | −2.89±0.16 | 2.70×10−3 | −5.71±0.84 | 1.35×10−3 |
| CD68 | CD68 antigen | −2.16±0.34 | 2.24×10−2 | 1.21±0.24 | 2.98×10−1 | 1.46±0.22 | 4.76×10−2 |
| CD74 | CD74 molecule, major histocompatibility complex, class II invariant chain | −2.18±0.50 | 4.56×10−2 | −2.33±0.69 | 2.54×10−2 | −2.37±0.57 | 1.54×10−2 |
| CDH1 | Cadherin 1, type 1, E-cadherin (epithelial) | −2.42±0.67 | 3.31×10−2 | −3.97±0.72 | 6.01×10−3 | −4.78±0.94 | 3.42×10−3 |
| CXCL2 | Chemokine (C-X-C motif) ligand 2 | −2.71±0.47 | 1.30×10−2 | −3.07±0.50 | 4.42×10−3 | −2.74±0.20 | 1.99×10−3 |
| CYP1A1 | Cytochrome P450, family 1, subfamily A, polypeptide 1 | 3.21±0.82 | 2.17×10−2 | 4.9±1.43 | 1.43×10−2 | 4.85±1.24 | 4.53×10−3 |
| CYP2E1 | Cytochrome P450, family 2, subfamily E, polypeptide 1 | 2.15±0.33 | 1.77×10−2 | 4.21±0.78 | 7.35×10−3 | 4.3±0.68 | 2.02×10−3 |
| DHX9 | DEAH (Asp-Glu-Ala-His) box polypeptide 9 | 3.05±0.65 | 1.78×10−2 | 2.45±0.66 | 3.27×10−2 | 4.59±0.92 | 1.49×10−3 |
| EBI3 | Epstein-Barr virus induced gene 3 | −2.37±0.22 | 1.66×10−2 | −2.8±0.40 | 6.80×10−3 | −1.77±0.31 | 1.73×10−2 |
| IGFBP3 | Insulin-like growth factor binding protein 3 | −3.19±0.41 | 1.09×10−2 | −3.36±0.92 | 7.05×10−3 | −3.77±1.06 | 3.95×10−3 |
| IKIP | IKK interacting protein | −1.39±0.04 | 4.49×10−3 | −1.8±0.17 | 2.51×10−2 | −5.2±0.06 | 1.94×10−5 |
| IL8 | Interleukin 8 | −2.04±0.29 | 1.94×10−2 | −1.35±0.23 | 7.96×10−2 | −6.66±0.66 | 1.40×10−3 |
| LTB | Lymphotoxin beta (TNF superfamily, member 3) | −5.15±1.69 | 1.88×10−2 | −9.95±2.42 | 5.90×10−3 | −5.07±1.12 | 4.87×10−3 |
| LTB4R | Leukotriene B4 receptor | 2.21±0.55 | 3.37×10−2 | 2.74±0.64 | 5.75×10−3 | 4.8±1.16 | 2.00×10−3 |
| MMP7 | Matrix metallopeptidase 7 (matrilysin, uterine) | −2.97±0.23 | 4.19×10−3 | −2.93±0.35 | 2.70×10−3 | −4.23±0.22 | 8.69×10−4 |
| PPAP2A | Phosphatidic acid phosphatase type 2A | −2.81±0.89 | 4.39×10−2 | −2.51±0.44 | 1.83×10−2 | −3.21±0.61 | 1.05×10−2 |
| RASSF1 | Ras association (RalGDS/AF-6) domain family 1 | 2.49±0.34 | 1.35×10−2 | 4.24±0.84 | 1.19×10−2 | 4.81±1.38 | 2.51×10−2 |
| SAA2 | Serum amyloid A2 | −2.08±0.34 | 2.25×10−2 | −4.48±0.77 | 3.66×10−3 | −7.18±0.86 | 1.86×10−3 |
| SPIB | Spi-B transcription factor (Spi-1/PU.1 related) | 3.34±0.80 | 2.12×10−2 | 6.82±1.67 | 6.33×10−3 | 6.95±1.86 | 6.94×10−3 |
| STAT1 | Signal transducer and activator of transcription 1, 91kDa | −2.28±0.24 | 1.88×10−2 | −3.34±0.63 | 6.61×10−3 | −4.21±0.42 | 2.86×10−3 |
| TCF3 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) | 2.01±0.14 | 8.79×10−3 | 2.24±0.33 | 1.65×10−2 | 1.61±0.11 | 3.94×10−3 |
| TNFRSF9 | Tumor necrosis factor receptor superfamily, member 9 | −2.45±0.37 | 9.97×10−3 | −3.76±0.16 | 8.99×10−4 | −6.05±0.58 | 6.01×10−4 |
| TRPV1 | Transient receptor potential cation channel, subfamily V, member 1 | 7.62±1.46 | 8.18×10−3 | 10.86±1.96 | 1.53×10−3 | 13.12±2.94 | 4.50×10−3 |
| UCP2 | Uncoupling protein 2 (mitochondrial, proton carrier) | −4.75±0.63 | 1.35×10−2 | −5.04±1.08 | 6.01×10−3 | −2.91±0.51 | 6.07×10−3 |
| VHL | Von Hippel-Lindau tumor suppressor | 4.19±0.54 | 7.12×10−3 | 2.49±0.62 | 3.96×10−2 | 4.12±0.71 | 5.83×10−3 |
aThe statistical analysis was performed by t-statistics. Genes with P<0.05 are listed.