Table 1. Summary of miRNAs involvement in adaptive immune response.
| miRNA | Function | Targets | References |
|---|---|---|---|
| miR-181a | Positive regulator of B-cell development and CD4+ T-cell selection, activation and sensitivity | SHP-2, PTPN22, DUSP5, DUSP6 | 19, 20 |
| miR-181b | Class switch recombination in activated B cells | AID | 21 |
| miR-155 | Required for T-cell differentiation, germinal center B-cell responses and responses to bacterial and viral infection | Maf, PU.1 | 25, 26, 27, 28 |
| miR-150 | Increased expression leads to suppression of B-cell formation by blocking in pro-B to pre-B cell transition. Decreased expression in chronic lymphocytic leukemia (CLL) | c-Myb | 22 |
| miR-146 | Negative regulator of TLR-NF-κB signaling in response to bacterial infections | IRAK1, TRAF6 | 35 |
| miR-326 | Involved in the regulation of Th17 differentiation and pathogenesis of autoimmune disease | Ets-1 | 31 |
| miR-126 | Involved in suppression of the effector function of Th2 cells and the development of allergic airways disease | POU domain class 2-associated factor 1 | 28 |
Abbreviations: AID, activation-induced cytidine deaminase; Ets-1, E26 transformation-specific-1; miRNA, microRNA; Th, T helper; TLR, Toll-like receptors.