Table 2. Summary of miRNAs involvement in autoimmune diseases.
| miRNA | Cell subsets influenced | Targets | Disease | References |
|---|---|---|---|---|
| miR-155 | Treg cells, activated B cells and monocytes, macrophages | SOCS1, PU.1, c-Maf, IKKε, FADD | RA | 35, 36 |
| miR-146 | Activated monocytes | IRAK1, TRAF6 | RA | 36 |
| miR-192 | Epithelial cell in colon tissues | MIP-2α | UC | 38 |
| miR-21 | Epithelial cell in colon tissues | ND | UC | 38 |
| miR-375 | β cells in pancreatic endocrine cells | Myotrophin | Diabetes | 41, 42 |
| miR-9 | ND | Pancreas granuphilin/Slp4 | Diabetes | 43 |
| miR-124a | β cells in pancreas | Foxa2 | Diabetes | 44 |
| miR-326 | Th17 cells | Ets-1 | MS | 31 |
| miR-18b | Human blood | ND | MS | 33 |
| miR-599 | Human blood | ND | MS | 33 |
| miR-96 | Human blood | ND | MS | 33 |
Abbreviations: Ets-1, E26 transformation-specific-1; MIP, macrophage-inflammatory peptide; miRNA, microRNA; MS, multiple sclerosis; ND, not determined; RA, rheumatoid arthritis; UC, ulcerative colitis; Th, T helper.