Figure 5.

Effects of paeonol on the peak amplitude of the I_A current of the RP4 neuron. A: Control I_A currents recorded in Na⁺-free solution. B, C, and D: I_A currents recorded at 20 min after paeonol (150 μmol/L), paeonol (500 μmol/L) and paeonol (1.5 mmol/L) administration, respectively. E: I_A currents recorded at 30 min after washing off from D. F: I_A currents recorded at 20 min after 4-AP (5 mmol/L) administration from E. G: Current-voltage relationships of the I_A currents before (•) and after paeonol administration at 500 μmol/L (○) and 1.5 mmol/L (▪), respectively. H: Voltage step commands. Note that paeonol (500 μmol/L and 1.5 mmol/L) significantly decreased the I_A at 20 min after treatment (^bP<0.05 vs control. n=3−4).