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. 2010 Nov 29;31(12):1583–1592. doi: 10.1038/aps.2010.202

Figure 5.

Figure 5

CpG-ODN reversed the immunosuppressive environment in the fibrotic renal tissue. (A) CpG-ODN reduced the expression of IL-13 (top panel) and TGF-β1 (bottom panel). (B) CpG-ODN inhibited the phosphorylation of Smad3. (C) CpG-ODN downregulated the expression of Stat3. (D) CpG-ODN blunted the activity of ERK. (E) CpG-ODN enhanced the activity of p38. (B–E) The top panel shows a representative Western blot, and the bottom panel presents the summarized results. Data are shown as mean±SEM (n=3). bP<0.05, cP<0.01 vs sham mice; eP<0.05, fP<0.01 vs UUO mice.