Table 3. Comparison of TGF-β1 and IFN-γ expression in the liver of patients and controls.
| Index | PBC (n=10) | Control (n=5) | t | P | |
|---|---|---|---|---|---|
| TGF-β1 | S (µm2) | 7779.81±4421.16 | 3888.00±1314.55 | 2.481 | 0.032 |
| IOD | 2773.57±896.60 | 1651.12±494.70 | 2.516 | 0.031 | |
| IFN-γ | S (µm2) | 16 131.61±3567.93 | 7937.88±2186.07 | −5.488 | 0.000 |
| IOD | 5458.45±1907.45 | 2869.76±858.78 | −3.620 | 0.003 | |
Expression of TGF-β1 and IFN-γ in the liver of PBC patients and healthy controls was analyzed by Image-Plus 6.0 software. Positive signals were evaluated by area (S) and accumulated optical density (IOD). The mean values were calculated from 10 independent areas by one pathologist using a high power lens (×400).
Abbreviations: IFN, interferon; PBC, primary biliary cirrhosis; TGF, transforming growth factor. t, t test.