Table 1. Allelic frequencies of KIR3DL1 and KIR3DS1 in Caucasian AS patients and healthy controls from Russian, Azorean, and Spanish populationsa.
| Allele | Frequency in AS patients % (number of alleles) | Frequency in control individuals % (number of alleles) | P value Russian AS versus Russian controls | OR (95% CI) Russian AS versus Russian controls | P value Combined Caucasian cohortsb | OR (95% CI) Combined Caucasian cohortsb | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| Russian (2n=166) | Spanish (2n=142) | Azorean (2n=110) | Russian (2n=214) | Spanish (2n=210) | Azorean (2n=114) | |||||
| 3DL1 | 69.3% (115) | 57% (81) | 64.5% (71) | 81.3% (174) | 77.6% (163) | 82.4% (94) | <0.01 | 0.52 (0.32–0.84) | <1×10−7 | 0.44 (0.33–0.60) |
| 3DS1 | 30.7% (51) | 42.9% (61) | 35.4% (39) | 18.7% (40) | 22.3% (47) | 17.5% (20) | <0.01 | 1. 93 (1.20–3.11) | <1×10−7 | 2.28 (1.70–3.05) |
a
Data for the Azorean and Spanish populations taken from Ref. 31.
b
Calculated for the combined cohorts of Russian, Spanish and Azorean AS patients and controls.
Abbreviations: AS, ankylosing spondylitis; CI, confidence interval; KIR, killer immunoglobulin-like receptor; OR, odds ratio.