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. 2010 Jun 4;31(6):746–752. doi: 10.1038/aps.2010.50

Table 4. The pharmacokinetic parameters of gemcitabine (dFdC) and its metabolite (dFdU) (n=7).

Compound Day Cmax (mg/L) t1/2 (h) AUC (mg·L−1·h) Vd (L/m2) CL (L·h−1·m−2)
dFdC d 1 13.71±3.85 0.42±0.20 12.2±4.56 28.8±22.3 118.9±51.5
  d 5 13.58±4.47 0.67±0.31 16.7±5.87 35.6±29.2 83.7±30.5
dFdU d 1 57.29±7.73 12.7±2.94 415±61.9 18.1±2.90 3.07±0.46
  d 5 59.87±9.42 12.7±3.13 435±70.1 17.5±2.91 2.94±0.51