Table 4. The pharmacokinetic parameters of gemcitabine (dFdC) and its metabolite (dFdU) (n=7).
Compound | Day | Cmax (mg/L) | t1/2 (h) | AUC (mg·L−1·h) | Vd (L/m2) | CL (L·h−1·m−2) |
---|---|---|---|---|---|---|
dFdC | d 1 | 13.71±3.85 | 0.42±0.20 | 12.2±4.56 | 28.8±22.3 | 118.9±51.5 |
d 5 | 13.58±4.47 | 0.67±0.31 | 16.7±5.87 | 35.6±29.2 | 83.7±30.5 | |
dFdU | d 1 | 57.29±7.73 | 12.7±2.94 | 415±61.9 | 18.1±2.90 | 3.07±0.46 |
d 5 | 59.87±9.42 | 12.7±3.13 | 435±70.1 | 17.5±2.91 | 2.94±0.51 |