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Treg cells inhibit OC formation and bone resorption via the secretion of IL-10 and TGF-β1. The formation of OCs (a) and the surface area of bone resorption lacuna (b) were evaluated after neutralization with antibodies against IL-10 and TGF-β1 in BMC and Treg cell cocultures. The data are expressed as mean±SD (n=5) *P<0.05, **P<0.01, compared with each other. BMC, bone marrow cell; NS, not significant; OC, osteoclast; TGF, transforming growth factor; Treg, regulatory T.
