Table 3. Mean pharmacokinetic parameters of omeprazole administered id to rabbits alone or 30 min after the id administration of 60 mg/kg ketoconazole or 9 mg/kg verapamil. n=6. Mean±SD. ^bP<0.05 vs the control (given omeprazole alone). CL/F: F is corresponded to the bioavailability.

	Omeprazole			Ketoconazole+Omeprazole	Verapamil+Omeprazole
	3 mg/kg	6 mg/kg	9 mg/kg	3 mg/kg	3 mg/kg
AUC(0–t) (μg/mL·h)	0.19±0.02b	0.46±0.19	0.68±0.17	0.92±0.23b	0.43±0.18b
Cmax (μg/mL)	0.24±0.04b	0.88±0.31	1.22±0.21	1.29±0.18b	0.86±0.16b
tmax (h)	0.2	0.15	0.15	0.15	0.2
t1/2 (h)	0.63±0.12	0.53±0.07	0.59±0.06	0.59±0.47	0.56±0.57
CL (L·h−1·kg−1)	15.32±1.12b	12.91±4.51	13.21±1.81	3.25±0.29b	6.85±0.58b