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The effects of ryanodine on PE-induced RC in intact thoracic aortic vessels. (A) 10 μmol/L ryanodine initially enhanced the amplitude of PE-induced RC and then abolished it; (B) PE-induced RC of the parallel control for (C) in a different vessel; (C) the dashed line shows that 10 μmol/L ryanodine abolished PE-induced RC. Thirty minutes after washout of ryanodine, repeated application of PE strikingly augmented the amplitude of PE-induced RC.
