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. 2009 Nov 5;30(11):1505–1512. doi: 10.1038/aps.2009.150

Figure 4.

Figure 4

Long-term baicalin administration downregulates the gene expression of SREBP-1c and fatty acid synthase (FAS) in the livers of rats fed a high-fat diet (HFD). Male Sprague-Dawley rats were fed a standard diet and treated with vehicle (STD+Veh) or fed a HFD and treated with vehicle (HFD+Veh) or baicalin (HFD+baicalin) at a dose of 80 mg/kg ip once a day for 16 weeks. The expression of SREBP-1c and FAS mRNAs in the liver was assayed by real-time quantitative PCR. Each bar represents the mean±SEM of RT-PCR analyses with the RNA samples from liver tissues of three to eight animals. All expression levels were normalized to the β-actin expression in the same PCR reaction. The ratio of mean expression in the STD liver was used as a control (1-fold). bP<0.05 vs respective HFD+Veh.