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TLR2 blockade inhibits vascular inflammation in atherosclerotic arteries. MMP-2 expression (A and B), NF-κB p65 phosphorylation (C), Stat3 phosphorylation (D) and the expression of the cytokines IL-6, TNF-α, and IL-10 (E) were reduced in the TLR2ab-treated and TLR2-deficient groups. The scale bars represent 50 μm. The data are shown as the mean±SEM (n=6 mice/group). bP<0.05 vs the saline-treated group.
