THA-hematoma cells incubated under hypoxia adapt to low oxygen partial pressure and express mRNA of angiogenic and inflammatory factors. mRNA expression of HIF1α (a), PGK1 (b), VEGF (c), IFN-γ (d), IL-6 (e) and IL-8 (f) were analyzed in THA-hematomas ex vivo (0 h) and after incubation under normoxia or hypoxia after 6 and 24 h. The mRNA expression was normalized to ACTB. Mann–Whitney U test, n=11, *P<0.05; **P<0.01; ***P<0.001. IFN-γ, interferon-gamma; IL, interleukin; THA, total hip arthroplasty; VEGF, vascular endothelial growth factor.