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Emodin decreased the food intake (A), body weight gain (B), mesenteric fat weight (C) and perirenal fat weight (D) of ob/ob mice. ob/ob mice were subjected to intraperitoneal injection twice daily with vehicle (0.5% Tween 80), 25 mg/kg emodin or 50 mg/kg emodin for 26 d. A pair-fed group was set by providing the ob/obmice each day with the amount of food eaten by freely fed 50-mg/kg emodin-treated mice. Values are expressed as the mean±SEM. cP<0.01 vs vehicle group; n=8.
