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. 2011 May 9;32(7):879–887. doi: 10.1038/aps.2010.229

Figure 1.

Figure 1

Metformin attenuates cardiac hypertrophy induced by TAC in WT mice. (A) Representative M-mode echocardiograms of the parasternal short-axis view at the level of the midpapillary muscle obtained in each group 6 weeks after sham or TAC operation. (B) Left ventricular posterior wall diameter in diastole (LVPWd) before the surgery and every week for 6 weeks after the surgery (□, sham+saline, ○, sham+ metformin, ▪, TAC+saline, and •, TAC+metformin; n=7–9). (C) The HW/TL was calculated 6 weeks after the sham or TAC operation (n=7–9). (D) HE staining of heart cross-sections (×400), bar=50 μm (E) Assessment of the myocyte cross-sectional cell area from left ventricular histological sections (n=6, each with a minimum of 100 cells counted). Quantitative real-time PCR analyses of ANF (F) and β-MHC (G) mRNA levels (n=4). The data are presented as means±SEM. bP<0.05, cP<0.01 vs sham+saline; eP<0.05 vs TAC+saline.