Table 2. Pharmacokinetic parameters of dehydrosilymarin suspension and dehydrosilymarin-loaded liposomal suspension (n=3, 80 mg/kg). Data expressed as mean±SD.
Parameters | Unit | Dehydrosilymarin | Dehydrosilymarin-loaded proliposomes |
---|---|---|---|
AUCt | μg·mL−1·h | 5.58±0.21 | 12.77±1.39 |
t1/2 | h | 20.63±5.03 | 7.48±0.30 |
tmax | h | 2.00 | 0.50 |
MRT | h | 21.33±0.24 | 6.98±0.71 |