Table 3. The correlative results of dehydrosilymarin powders and dehydrosilymarin-loaded proliposomes in vitro and in vivo (Checked the critical value table for r, when the degree of freedom v was 8, critical value r8, 0.05=0.632, which showed the correlation coefficients of regression equations of drugs r>r8, 0.05).
| Formulation type | t (h) | 0.25 | 0.5 | 1 | 2 | 3 | 4 | 6 | 8 | 10 | 12 | r |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Powders | Fr (%) | 3.67 | 5.81 | 9.58 | 11.73 | 13.76 | 15.22 | 16.31 | 18.24 | 19.67 | 20.17 | 0.9886 |
| in pH 1.2 | Fa (%) | 41.59 | 58.40 | 63.18 | 72.34 | 78.32 | 83.56 | 89.04 | 92.90 | 94.36 | 100.0 | |
| Proliposomes | Fr (%) | 2.30 | 2.40 | 2.51 | 2.67 | 3.19 | 3.71 | 3.85 | 4.38 | 4.46 | 5.22 | 0.9594 |
| in pH 1.2 | Fa (%) | 25.33 | 40.12 | 40.76 | 44.57 | 46.84 | 51.29 | 61.89 | 81.08 | 91.19 | 100.0 | |
| Powders | Fr (%) | 4.81 | 5.61 | 7.99 | 12.46 | 19.96 | 26.15 | 33.00 | 40.83 | 44.66 | 48.04 | 0.9362 |
| in pH 6.8 | Fa (%) | 41.59 | 58.40 | 63.18 | 72.34 | 78.32 | 83.56 | 89.04 | 92.90 | 94.36 | 100.0 | |
| Proliposomes | Fr (%) | 10.75 | 17.15 | 20.73 | 26.68 | 34.97 | 39.57 | 54.02 | 70.65 | 80.08 | 86.41 | 0.9887 |
| in pH 6.8 | Fa (%) | 25.33 | 40.12 | 40.76 | 44.57 | 46.84 | 51.29 | 61.89 | 81.08 | 91.19 | 100.0 |