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. 2011 Jun 13;32(7):973–980. doi: 10.1038/aps.2011.25

Table 3. The correlative results of dehydrosilymarin powders and dehydrosilymarin-loaded proliposomes in vitro and in vivo (Checked the critical value table for r, when the degree of freedom v was 8, critical value r8, 0.05=0.632, which showed the correlation coefficients of regression equations of drugs r>r8, 0.05).

Formulation type t (h) 0.25 0.5 1 2 3 4 6 8 10 12 r
Powders Fr (%) 3.67 5.81 9.58 11.73 13.76 15.22 16.31 18.24 19.67 20.17 0.9886
in pH 1.2 Fa (%) 41.59 58.40 63.18 72.34 78.32 83.56 89.04 92.90 94.36 100.0  
Proliposomes Fr (%) 2.30 2.40 2.51 2.67 3.19 3.71 3.85 4.38 4.46 5.22 0.9594
in pH 1.2 Fa (%) 25.33 40.12 40.76 44.57 46.84 51.29 61.89 81.08 91.19 100.0  
Powders Fr (%) 4.81 5.61 7.99 12.46 19.96 26.15 33.00 40.83 44.66 48.04 0.9362
in pH 6.8 Fa (%) 41.59 58.40 63.18 72.34 78.32 83.56 89.04 92.90 94.36 100.0  
Proliposomes Fr (%) 10.75 17.15 20.73 26.68 34.97 39.57 54.02 70.65 80.08 86.41 0.9887
in pH 6.8 Fa (%) 25.33 40.12 40.76 44.57 46.84 51.29 61.89 81.08 91.19 100.0