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Mean plasma concentration-time profiles of losartan after iv (3 mg/kg) administration to rats without and with ticlopidine at doses of 4 and 10 mg/kg. Mean±SD (n=6). –•–: Control (only losartan 3 mg/kg alone); –○–: Losartan 9 mg/kg+ticlodipine 4 mg/kg; –▾–: Losartan 9 mg/kg+ticlodipine 10 mg/kg.
