. 2011 Jun 13;32(7):967–972. doi: 10.1038/aps.2011.32

Table 1. Pharmacokinetic parameters of losartan after oral (9 mg/kg) administration without (control) and with ticlopidine at doses of 4 and 10 mg/kg. n=6. ^bP<0.05 vs control group (only losartan alone).

Parameter	Control	Losartan+Ticlodipine
Parameter	Control	4 mg/kg	10 mg/kg
AUC_0–∞ (ng·mL⁻¹·h)	143.1±33.2	178.9±34.9	236.0±39.6^b
C_max (ng/mL)	15.6±2.2	17.6±3.0	23.3±3.7^b
t_max (h)	1.00±0.55	1.00±0.55	0.84±0.26
t_1/2 (h)	9.40±1.51	9.60±1.54	9.61±1.64
F (%)	15.6±3.6	19.5±4.7	25.7±5.2^b
RB (%)	100	125	165

AUC_0–∞, total area under the plasma concentration-time curve from time zero to infinity; C_max, peak plasma concentration; t_max, time to reach the peak plasma concentration; t_1/2, terminal half-life; F, extent of absolute oral bioavailability; RB, relative bioavailability.

Table 1. Pharmacokinetic parameters of losartan after oral (9 mg/kg) administration without (control) and with ticlopidine at doses of 4 and 10 mg/kg. n=6. bP<0.05 vs control group (only losartan alone).

Table 1. Pharmacokinetic parameters of losartan after oral (9 mg/kg) administration without (control) and with ticlopidine at doses of 4 and 10 mg/kg. n=6. ^bP<0.05 vs control group (only losartan alone).