. 2011 Jun 13;32(7):967–972. doi: 10.1038/aps.2011.32

Table 2. Pharmacokinetic parameters of EXP-3174 after oral (9 mg/kg) administration without (control) and with ticlopidine at doses of 4 and 10 mg/kg. n=6. ^bP<0.05 vs control group (only losartan alone).

Parameter	Control	Losartan+ticlodipine
Parameter	Control	4 mg/kg	10 mg/kg
AUC_0–∞ (ng·mL⁻¹·h)	206.1±33.1	211.0±41.5	292.3±44.8^b
C_max (ng/mL)	17.4±2.40	19.8±3.18	23.8±4.72
t_max (h)	2.00±0.63	2.00±0.63	1.68±0.52
t_1/2 (h)	7.21±1.07	7.66±1.82	8.33±2.08
AUC_EXP-3174/AUC_losartan	1.44±0.23	1.19±0.19	1.23±0.29

AUC_0–∞, total area under the plasma concentration-time curve from time zero to infinity; C_max, peak plasma concentration; t_max, time to reach the peak plasma concentration; t_1/2, terminal half-life.

Table 2. Pharmacokinetic parameters of EXP-3174 after oral (9 mg/kg) administration without (control) and with ticlopidine at doses of 4 and 10 mg/kg. n=6. bP<0.05 vs control group (only losartan alone).

Table 2. Pharmacokinetic parameters of EXP-3174 after oral (9 mg/kg) administration without (control) and with ticlopidine at doses of 4 and 10 mg/kg. n=6. ^bP<0.05 vs control group (only losartan alone).