Table 3. Pharmacokinetic parameters of losartan after intavenous (3 mg/kg) administration to rats without (control) and with ticlopidine at doses of 4 and 10 mg/kg. n=6.
| Parameter | Control | Losartan+ticlodipine | |
|---|---|---|---|
| 4 mg/kg | 10 mg/kg | ||
| AUC0–∞ (ng·mL−1·h) | 288.1±74.2 | 314.2±81.2 | 345.0±85.1 |
| CLt (mL·h−1·kg−1) | 3.78±1.07 | 3.56±1.02 | 3.33±1.01 |
| t1/2 (h) | 8.7±2.0 | 8.8±2.0 | 8.9±2.2 |
| RB (%) | 100 | 108 | 119 |
AUC0–∞, total area under the plasma concentration-time curve from time zero to infinity; CLt, total body clearance; t1/2, terminal half-life; RB, relative bioavailability.