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. 2011 Feb 14;8(2):181–188. doi: 10.1038/cmi.2010.84

Figure 1.

Figure 1

TLR9-dependent and -independent signals involved in VZV-induced IFN-α production. (a) The IFN-α production of PBMCs induced by TLR9 agonist (sCpG) was inhibited by iCpG. (b) The IFN-α production of PBMCs induced by VZV was partially inhibited by inhibitory CpG and UV light inactivation. (sCpG: 5 µg/ml; iCpG: 100 µg/ml) (UV crosslinker 1 J/cm2×5 min) *P<0.01 VZV versus VZV+iCpG and VZV versus UV-VZV, **P<0.05 VZV+iCpG versus UV-VZV+iCpG and UV-VZV versus UV-VZV+iCpG. Data presented were calculated from six replicated experiments. iCpG, inhibitory CpG; IFN, interferon; NC, negative control; ND, non-detectable; PBMC, peripheral blood mononuclear cell; sCpG, stimulatory CpG; TLR, Toll-like receptor; VZV, varicella-zoster virus.