Figure 5.
Protective effect of 6-shogaol against MPTP-induced dopaminergic neuron damage in a mouse PD model. Seven days after 6-shogaol and/or MPTP treatment, tyrosine hydroxylase (TH) tyrosine hydroxylase was detected immunohistochemically. Dopaminergic cells were quantified by counting the number of TH-immunoreactive cells in the ST(A) and by measuring the optical intensity in the SNpc(B). Representative photomicrographs are shown (C). Scale bar=200 μm. Values are indicated as mean±SEM. cP<0.01 compared with the control group. fP<0.01 compared with the MPTP-only treated group.