Table 1. Effects of SKF83959 and DOV21947 on the uptake activity of SERT, NET, and DAT.
| |
|
Compound |
|
|---|---|---|---|
| DOV21947 | SKF83959 | ||
| SERT | Maximal inhibiting ratio | 95.10%±1.55% | 97.35%±0.78% |
| IC50 (95% CI) (nmol/L) | 187 (100–533) | 242 (148–346) | |
| NET | Maximal inhibiting ratio | 99.65%±0.39% | 98.14%±2.17% |
| IC50 (95% CI) (nmol/L) | 93.5 (22.3–101) | 381 (233–672)b | |
| DAT | Maximal inhibiting ratio | 99.45%±0.74% | 99.20%±2.28% |
| IC50 (95% CI) (nmol/L) | 533 (335–828) | 1375 (1140–3170)b | |
The parameters were obtained from Figure 1. The values of IC50 were expressed as mean [95% confidence interval (95% CI)]. The difference between IC50 was tested by weighted probit analysis. Maximal Inhibiting ratio was expressed as mean±SEM. The nonspecific uptake activity was defined using Na+-free HBSS. bP<0.05 vs DOV21947.