Table 3. Atherosclerotic lesions of WT and ApoE−/− mice. Results are expressed as the mean±SD. LA, lumen area; PA, plaque area; CA, collagen area. cP<0.01 vs WT mice. fP<0.01 vs ApoE−/− control mice. iP<0.01 vs atorvastatin treatment group. lP<0.01 vs low-dose β3-AR agonist treatment group.
| n | WT | Control | Atorvastatin | Low dose agonist | High dose agonist | Antagonist | |
|---|---|---|---|---|---|---|---|
| LA (×104 μm2) | 6 | 60.83±2.44 | 42.02±2.30c | 50.36±2.42cf | 46.67±2.39cfi | 50.27±1.45cfl | 41.53±2.30c |
| PA (×104 μm2) | 6 | 0 | 21.26±2.47c | 12.39±1.40cf | 16.60±1.35cfi | 11.94±0.92cfl | 19.92±1.04c |
| CA (×104 μm2) | 6 | 0 | 9.88±1.32c | 3.45±0.77cf | 5.20±1.02cfi | 3.46±0.83cfl | 9.74±1.12c |
| PA/LA (%) | 6 | 0 | 50.82±7.43c | 24.56±1.97cf | 35.57±2.51cfi | 23.80±2.39cfl | 48.11±4.20c |
| CA/PA (%) | 6 | 0 | 47.19±9.35c | 27.90±5.71cf | 31.30±5.64cfi | 29.11±7.54cfl | 49.07±6.94c |