Table 1. Phenotypical heterogeneity and functional package organization of human γδ T cells.
| Subset | γδ1 | γδ2 | γδ17 | γδ22 | γδFH | γδreg |
|---|---|---|---|---|---|---|
| Polarizing cytokine | IL-12 | IL-4 | IL-1-β, IL-6, IL-23, TGF-β | ? | IL-21 | IL-15, TGF-β |
| Transcription factor | T-bet, Eomes | GATA-3 | RORC, AHR | ? | Bcl-6 | Foxp3 ? |
| Homing receptors | CXCR3, CCR5 | ? | CCR6 | ? | CXCR5 | ? |
| Effector molecules | TNF-α, IFN-γ | IL-4 | IL-17 | IL-22 | IL-4, IL-10 | ? |
| Target cells | Macrophages, Dendritic cells | ? | Neutrophils, Epithelial cells | ? | B cells | T cells |
| Function | Intracellular bacteria | ? | Extracellular bacteria | ? | Antibody production | Regulation |
Abbreviations: IFN, interferon; TGF, transforming growth factor; TNF, tumor-necrosis factor.