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. 2014 May;143(5):645–656. doi: 10.1085/jgp.201311036

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© 2014 Pless et al.

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Figure 3. — Removing the negative charge in the INC has little effect on channel activation. (A and B) G-V (A) and SSI curves (B) for WT and mutants in which the S2 INC was neutralized through introduction of Nha or Gln (DI, Glu171TAG + Nha; DII, Glu624Gln; DIII, Glu1079Gln; DIV, Glu1399TAG + Nha). (C and D) G-V (C) and SSI curves (D) for WT and mutants in which the S3 INC was neutralized through the introduction of Asn (DI, Asp197Asn; DII, Asp646Asn; DIII, Asp1101Asn; DIV, Asp1420Asn). The insets in B and D show bar graphs representing the average time constants for fast inactivation (τ) for a depolarizing voltage step to −15 mV. *, statistical difference to WT values in an unpaired t test (P < 0.01).