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. 2014 May;143(5):633–644. doi: 10.1085/jgp.201311112

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© 2014 Gao et al.

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Figure 6. — ¹O₂ modification of the mHCN2 channel is state dependent. (A) Schematic drawings of closed and open channels. (B) Laser pulses were delivered preceding the hyperpolarization step. (C) Current traces before (black; no. 3 in D and E) and after (blue; no. 7 in D and E) laser treatments. (D and E) Normalized τ_deactivation or percentage of I_inst versus episode number. 0.5 µM FITC-cAMP was applied to the bath. *, P < 0.05.