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. 2014 May;143(5):577–604. doi: 10.1085/jgp.201311123

Figure 19.

Figure 19.

Phase-plane loops of voltage versus NCX current, SR calcium release flux, and JSR calcium, for the conditions shown in Fig. 18 (A–C). In the presence of normal RyR sensitivity, diastolic release is apparent at voltages below −50 mV and alters the shape of the INCX loop, producing an inward (downward) slope at low voltages that drives the membrane to threshold.